Investigating suspected immune deficiency in children

The International Union of Immunological Societies now recognizes over 430 single gene inborn errors immunity, making the investigation suspected immunodeficiency in children increasingly complex. use immunomodulatory therapies, including biologics, may also cause both transient and permanent secondary immunodeficiency. This review outlines a practical approach to guide paediatric doctors allied health professionals investigating with immune deficiency, starting detailed clinical assessment history examination, as well baseline investigations exclude screen for organ-specific complications should be followed appropriate by basic humoral, cell-mediated, phagocytic, innate results which would instruct necessity confirmatory testing using functional protein expression assays, genetic testing. authors recommend an screening asymptomatic neonates, strong family primary immunodeficiency, or those diagnosed syndromes associated